Focal Segmental Glomerulosclerosis (FSGS)

Focal Segmental Glomerulosclerosis is a disease that leads to nephrotic syndrome by scarring the kidney’s filtering system. There are up to 1 million tiny microscopic filters in the kidney called glomeruli. They work like a sieve that you would find in a kitchen, they filter the blood taking out the water-like part that becomes urine and leaves the protein in the blood. If the glomeruli become scarred, they allow proteins that should be in the blood to leak into the urine.

With FSGS only some sections of some glomeruli become scarred. This can only be diagnosed by reviewing kidney biopsy samples.

In addition to our general nephrotic syndrom studies, we are doing research to find alternative treatments for FSGS patients who do not respond to conventional medications, or who have stopped responding to their original medicines.